Preimplantation genetic testing

Preimplantation genetic testing is based on the whole genome SNP array on single or multiple cells isolated from the embryos, using the world's leading karyomapping technology to select for the best embryo with normal phenotypes. It can successfully block the transmission of single gene disease / balanced chromosome translocation to the next generation.

Technical principle

The whole genome SNP array based karyomapping technology comprehensively analyzes the SNPs across the chromosomes of father, mother and proband, then constructs the haplotypes of father and mother, respectively, and determines the unique DNA fingerprints (haplotypes) carrying the defective genes. The haplotypes of candidate embryos are analyzed to detect whether the embryos carries DNA fingerprints of defective genes. If the embryo contains the DNA fingerprint, it indicates that the embryo is defective; if the embryo does not contain the DNA fingerprint, it indicates that the embryo is good for transfer.

Technological advantage

Avoid misdiagnosis and false negative caused by allele dropout of traditional PCR technology

can diagnose any single gene disease with clear genetic causes

One test to complete PGs + PGD at the same time, improving pregnancy rate

Accurate differentiation of normal, balanced translocation and Robertsonian translocation embryos