1. What is pre-implantation genetic screening PGT-A?
Preimplantation genetic screening refers to the detection of chromosome number and structural abnormalities in embryos that develop to the 3rd or 5th day. The test data will help doctors choose embryos with normal chromosome numbers and structures to be transplanted into the mother. At present, the more advanced detection method is to use biochip technology to comprehensively screen 46 chromosomes of embryos, so as to select embryos with normal chromosome number and structure for transplantation. Using this test can increase the clinical pregnancy rate of patients, reduce the risk of early abortion, and reduce birth defects.
2. What is aneuploidy and what are the common related diseases?
Aneuploidy is a cell that lacks or adds one or more complete chromosomes and partial chromosomal fragments to the chromosome. It is used to describe chromosomal abnormalities. A healthy human body has 23 pairs of chromosomes (22 pairs of autosomes and 1 pair of sex chromosomes), with a total of 46 pairs.
In fact, in the treatment of IVF, more than 50% of early aborted embryos are caused by aneuploidy. In addition, aneuploidy can cause stillbirth, birth defects, etc. Common non-global related diseases include trisomy 21 (innate fool type), trisomy 18, and trisomy 13. Down syndrome is manifested as mental retardation, malformations, and an average life expectancy of 35 to 50 years. Embryos of trisomy 18 and trisomy 13 are abnormally developed in the brain, bones, heart, reproductive organs and other tissues, and they will have high abortion rates, and newborns will die shortly after birth.
3. Why does aneuploidy increase with age?
Every woman has a fixed number of follicles in her ovaries from birth. This number decreases with age. A healthy woman will differentiate into a mature egg every month. However, as you age, these preserved follicles will gradually age. During the process of differentiation of these senescent follicles into mature eggs, the number of chromosomes may be lost or increased, and the structure may be abnormal, resulting in aneuploid eggs.

4. How does Preimplantation Genetic Testing for Aneuploidies help patients?
Preimplantation genetic screening is to test the number and structure of 46 chromosomes for each individual embryo, and select embryos with normal chromosome number and structure to implant into the mother. Transplanting embryos with a normal number of chromosomes will greatly increase the clinical pregnancy rate, reduce the risk of early abortion, and reduce the birth rate of children with aneuploidy-related diseases.